Oral Ulcer Therapeutic R&D

Overview

Oral ulcers fall under TCM categories of "mouth sores," "oral erosion," and "oral ulcers." The 'Spiritual Pivot - Pulse Degree' states: "Spleen qi connects to the mouth; its brilliance shows in the lips." The 'Treatise on the Origins of Diseases' explains: "Mouth sores arise when heart and lung have heat; heart qi connects to the tongue, spleen qi to the mouth — heat overflows with qi, causing sores on the tongue and mouth." The condition commonly results from heart-spleen heat flaring upward, yin-deficiency with deficiency-fire, or spleen-stomach damp-heat steaming the mucosa. ZhengYiKang's Oral Ulcer therapeutic R&D achievement employs "clearing heat and draining fire; nourishing yin and astringing sores; detoxifying and promoting tissue repair" as its treatment R&D approach.

R&D & Clinical Progress

This is a genuine ZhengYiKang TCM therapeutic R&D program targeting disease mechanisms through formula innovation and pharmacological research. **We are actively preparing large-scale clinical trial subject recruitment and submitting registration/approval materials to the relevant authorities.**

Until national drug or related registration approval is obtained, website content reflects R&D progress and clinical preparation only — not marketing of an approved drug. Patients must strictly follow physician guidance; never stop, reduce, or replace standard medical treatment on your own.

Herb Properties & Meridian Tropism

Mechanism of Action

The mouth is the orifice of the spleen; the tongue is the sprout of the heart — the Heart and Spleen meridians are most closely related to oral mucosa. When heart-spleen heat accumulates, fire flares upward and scorches the mucosa into ulcers; yin deficiency allows deficiency-fire to float upward, causing recurrent, slow-healing sores. This formula uses herbs entering the Heart, Spleen, and Stomach meridians, guiding medicinal power upward to the oral cavity: clearing heart-spleen excess fire to cut off the source of ulcer formation; nourishing yin and subduing fire to repair mucosa damaged by deficiency-fire; detoxifying, astringing sores, and promoting tissue repair to accelerate healing.

Therapeutic Research Directions

Suitable Scenarios

Usage

During active ulcers: 3–4 times daily, 1 sachet each time — brew with warm water, gargle 2–3 minutes then swallow slowly, or apply to the lesion. After relief: twice daily after meals for 5–10 days per course. Recurrent cases: 2–3 consecutive courses of 30 days recommended.

Preliminary Research Observations (not formal clinical trial data, for reference only)

Most users report noticeable pain relief and smaller ulcer size within 2–3 days during active flares. Those completing 2+ courses for recurrent ulcers report longer intervals between episodes, fewer sores, and significantly improved comfort when eating and speaking.